Recherche

Our role Gastroenterology is the medico-technical discipline concerned with digestive pathologies, that is, pathologies of the digestive tract - from the mouth to the anus – and the organs and glands situated in the abdomen: liver, pancreas and gall bladder.  Image Although we are separate entities, in practice we form together with digestive surgery and digestive oncology a large medico-surgical department that treats digestive pathologies. Within which our patients often follow integrated care pathways. Our specialities The Erasmus Hospital's Medical Gastroenterology Department spans 7 clinics that correspond to recognised fields of expertise:The Intestinal Diseases Clinic (examples: Crohn's disease,  cœliac disease, ulcerative colitis, auto-immune diseases)  The Digestive Endoscopy Clinic The Liver Disease Clinic that is a reference centre, especially for advanced liver diseasesThe Liver Transplant Clinic that carries out liver transplants The Functional Digestive Pathologies Clinic – pathologies that are the number one reason for consultations in gastroenterology – that proposes, in particular, a digestive comfort consultation for irritable intestine syndrome and gastro-oesophageal reflux, for example   The Pancreatic Diseases and Nutritional Support Clinic that treats non-cancerous pancreatic diseases (e.g. pancreatitis), problems of (mal)nutrition and parenteral feeding, at hospital or at home     The Integrated Obesity Centre. Our team Image Our specialist doctors Focus The Erasmus Hospital Medical Gastroenterology Department is a reference centre – and reputed training centre – for endoscopy, for purposes of diagnosis and treatment.  New procedures at the leading edge of technology are studied here.  Cooperation with the ULB's Polytechnic Faculty has even permitted the development of an endoscope able to carry out partial gastric sleeve surgery. This procedure has shown its effectiveness in weight loss among obesity patients.   Research Thanks to its large "biobank", the Medical Gastroenterology Department works with the ULB's Experimental Gastroenterology Laboratory in pursuing 3 main lines of translational research:  liver diseases and cancerschronic inflammatory bowel diseasespancreatic cancers.A clinical research unit permits access to innovative treatments, notably in oncology, hepatology and inflammatory bowel diseases.   Publications Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study Authors: Eric Trépo, PhD *, Stefano Caruso, PhD *, Jie Yang, PhD *, Sandrine Imbeaud, PhD, Gabrielle Couchy, PhD, Quentin Bayard, PhDJournal : The Lancet Oncology, Volume 23, Issue 1, January 2022 Endoscopic sutured gastroplasty in addition to lifestyle modification: short-term efficacy in a controlled randomised trial Authors: Vincent Huberty, Ivo Boskoski, Vincenzo Bove, Pauline Van Ouytsel, Guido Costamagna, Marc A Barthet, Jacques DevièreJournal : Gut-Bmj Journal, published October 28, 2020 Collecting New Peak and Intermediate Infliximab Levels to Predict Remission in Inflammatory Bowel Diseases Authors: Claire Liefferinckx, Jérémie Bottieau, Jean-François Toubeau, Debby Thomas, Jean-François Rahier, Edouard Louis, Filip Baert, Pieter Dewin, Lieven Pouillon, Guy Lambrecht, François Vallée, Severine Vermeire, Peter Bossuyt, Denis FranchimontJournal : Inflammatory Bowel Diseases, Volume 28, Issue 2, February 2022, Pages 208–217 Long-term outcomes in patients with decompensated alcohol-related liver disease, steatohepatitis and Maddrey's discriminant function Authors: Delphine Degré, Rudolf E. Stauber, Gaël Englebert, Francesca Sarocchi, Laurine Verset, Florian Rainer, Walter Spindelboeck, Hassane Njimi, Eric Trépo, Thierry Gustot, Carolin Lackner, Pierre Deltenre, Christophe Moreno Journal : Journal of Hepatology, 2020, vol. 72

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Our role Genetics is the study of the transmission of hereditary traits. In medicine it involves sequencing, "reading" and characterising the genome, that is, the totality of a person's genetic material (chromosomes and genes).  To learn more about the Genetics Centre, click here. Image Image Image Image Our speciality is transverse and concerns all medical disciplines and all ages of life. At present, our focus is on rare diseases. But in a near future genetics will be used increasingly for more common pathologies. Pr Guillaume Smits Director of the ULB's Human Genetics Centre Our specialities The ULB's Human Genetics Centre is organised in 5 sectors: Preconception genetics aims to determine the risk of transmitting a genetic disease to descendants. In the case of in vitro fertilization (IVF), the preimplantation diagnosis makes it possible to select and implant embryos that do not carry the said disease (examples: cystic fibrosis, spinal muscular atrophy, sickle cell anaemia, etc.)    Prenatal genetics makes it possible to confirm or specify certain pathologies with which a foetus is already infected. Examples: Down syndrome, malformations, intellectual deficiency, etc.  Paediatric genetics: More than 70% of rare diseases are paediatric. Genetics makes it possible to make or refine a diagnosis, to avert the development and/or complications of the disease or to propose a treatment.   Adult genetics: A growing number of medical specialities have increasing recourse to genetic tests when treating certain diseases.   Oncogenetics has two principal fields of action:  Predictive genetics aims to detect and quantify hereditary risks of cancer, in particular within the same family. Example: mutations of BRCA-1 and -2 that predispose women to breast and ovarian cancer.   Pharmacogenetics involves checking whether a patient carries a gene that would respond positively to (cancer) treatment.    Our team Image Our specialist doctors Focus The ULB's Human Genetics Centre analyses samples collected within the  CHORUS network (that brings together the hospitals of the Brussels University Hospital (HUB), the Iris network and the CHIREC group) and the Tivoli and Ambroise Paré University Hospitals with a view to genetic testing. The department cooperates with each of the 7 Belgian genetic centres for certain tests.    Research The ULB's Human Genetics Centre carries out research on what genetic testing of the future could be:  sequencing of the entire genome; methylome sequencing, which can reveal certain rare diseases;   transcriptome analysis to identify what genes use what kind of cell;   very long genome sequences to characterise complex zones and variants in the DNA.  Publications Implementation of fetal clinical exome sequencing: Comparing prospective and retrospective cohorts Authors : M. Marangoni et al.Journal : Genet Med. 2022 Feb;24(2):344-363. doi: 10.1016/j.gim.2021.09.016. Epub 2021 Nov 30. PMID: 34906519  Toward reporting standards for the pathogenicity of variant combinations involved in multilocus/oligogenic diseases Authors : Sofia Papadimitriou et al.Journal : HGG Adv. 2022 Dec 2;4(1):100165. doi: 10.1016/j.xhgg.2022.100165. eCollection 2023 Jan 12. PMID: 36578772  A form of muscular dystrophy associated with pathogenic variants in JAG2 Authors : Sandra Coppens et alJournal : Am J Hum Genet. 2021 May 6;108(5):840-856. doi: 10.1016/j.ajhg.2021.03.020. Epub 2021 Apr 15. PMID: 33861953  Genetic testing in autoinflammatory diseases - past, current and future perspectives Authors : Anouk Le Goueff et al.Journal : Eur J Intern Med. 2022 Dec;106:71-79. doi: 10.1016/j.ejim.2022.08.020. Epub 2022 Sep 22. PMID: 36153184 DOI: 10.1016/j.ejim.2022.08.020